The adipose tissue is a central hub of metabolic and endocrine regulation with a major impact on aging. We identify the conserved miRNA-processing enzyme Dicer-1 (Dcr-1) as a crucial regulator of ...
Differentiation of induced pluripotent stem cells (iPSCs) toward neuronal lineages has enabled diverse cellular models of human neurodevelopment and related disorders. Here, we jointly profiled ...
This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Thanks to the plummeting costs of continuously evolving omics analytical platforms, ...
Vein graft failure following cardiovascular bypass surgery results in significant patient morbidity and cost to the healthcare system. Vein graft injury can occur during autogenous vein harvest and ...
Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques is predictive for the risk of ...
1 Department of Laboratory, Yangbi Yi Autonomous County People’s Hospital, Dali, China. 2 Department of Obstetrics and Gynecology, Yangbi Yi Autonomous County People’s Hospital, Dali, China. 3 ...
Background: Esophageal carcinoma (ESCA) is one of the most prevalent malignant tumors in the world. The prognosis of patients has significantly improved with the development of surgery, targeted ...
Some organisms have the fascinating capacity to regenerate lost body parts. To which extent regeneration entails the redeployment of an embryonic developmental program is a long-standing question of ...
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